Library
Epidemic potentialMOL · MolecularMPOX
Mpox / orthopox virus DNA
Monkeypox virus
Last reviewed 2026-08-13
Public health significance
Clade I vs clade II changes the public-health response. Generic orthopox is not the whole answer.
Specimen types
Lesion swab
Method
NAA, generic orthopox and/or clade-specific
CLIA / validation
Use CDC LIVD mappings. Clade-specific assays may be LDT.
Interpretation
Detected / Not detected. State the target (generic orthopox vs clade).
Reflex / referral
Clade typing when a generic assay is positive and typing is not already on the first run.
Quality control
Positive control for the target you report. Separate clade I material per current biosafety rules.
Reportability
High. Rapid notification in most jurisdictions.
HL7 / ELR
CDC Monkeypox LIVD file. Target-specific LOINCs when available (e.g. 100434-0 family).
Sources
CDC mpox LIVD; APHL orthopox guidance.